Clean-in-place (cip) systems for lab bioreactors – best practices?

[Keney]

Hey everyone! I’m looking to integrate a Clean-in-Place (CIP) system into my laboratory bioreactors to improve efficiency and sterility. I mainly work with glass, autoclavable bioreactors (3L–10L) for microbial and cell culture applications. Has anyone successfully set up a semi-automated or automated CIP system for lab-scale use? Would love to hear your experiences and recommendations!

[Aymeta]

Hey! I recently integrated a semi-automated CLEAN-IN-PLACE SYSTEMS https://brsbiotech.com/catalog/stain...place-systems/ into my glass bioreactors (3L-10L) for microbial and cell culture applications, and it's made a huge difference in efficiency and sterility. I went with a setup from BRS Biotech, which provides great flexibility for lab-scale use. The automated cleaning cycles reduce downtime, and I’ve noticed a significant improvement in cleanliness between batches. For anyone looking to optimize, make sure to consider system compatibility with your glass bioreactors and automate as much as possible for consistent results!

[Fioeynau]

Good points! I was thinking of using a mobile CIP skid but wasn’t sure if it would be effective on smaller glass reactors. Do you recommend any specific detergents or CIP validation methods?